Acetyl-L-carnitine
500 mg, 100 capsules

A major cause of aging is the deterioration of the energy-producing components of the cell, which results in reduced cellular metabolic activity, the accumulation of cellular debris, and eventual death of the cell.

L-carnitine helps to maintain cellular energy metabolism by assisting in the transport of fat through the cell membrane and into the mitochondria within the cell, where these fats are oxidized to produce the cellular energy ATP.

Acetyl-L-carnitine is the acetylated ester of the amino acid L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane compound that helps to maintain mitochondrial bioenergetics and lowers the increased oxidative stress associated with aging. Acetyl-L-carnitine and L-carnitine are absorbed into the bloodstream efficiently and both are very effective at carrying fatty acids across the membrane into the cell where they are burned as energy and utilized efficiently in the mitochondria of the cell. Acetyl-L-carnitine also guards against oxidative damage. Amyloid-beta peptide is a principal component of senile plaques and is thought to be central to the pathogenesis of degenerating process.

Acetyl-L-carnitine exerts protective effects against Abeta neurotoxicity and oxidative stress.

About 95% of cellular energy occurs in the mitochondria. Acetyl-L-carnitine (ALC) is the biologically active amino acid involved in the transport of fatty acids into the cell’s mitochondria for the purpose of producing energy. ALC influences the maintenance of key mitochondrial proteins for maximum energy production. ALC easily crosses the blood-brain barrier and may have potential in exerting unique neuroprotective, neuromodulatory, and neurotrophic properties. ALC may improve the age-associated decline of memory, improve mitochondrial structure and function, inhibit the age-associated increase of oxidative damage, elevate the levels of antioxidants, and restore the activity of key enzymes.

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Acetyl-L-Carnitine Arginate
100 Capsules

A major cause of aging is the deterioration of the energy-producing components of the cell, which results in reduced cellular metabolic activity, the accumulation of cellular debris, and eventual death of the cell.

L-carnitine helps to maintain cellular energy metabolism by assisting in the transport of fat through the cell membrane and into the mitochondria within the cell, where these fats are oxidized to produce the cellular energy ATP.

Acetyl-L-carnitine arginate is a patented form of carnitine that stimulates the growth of neurites in the brain. Studies show that acetyl-L-carnitine arginate stimulates the growth of neurites by 19.5%, which is almost four times better than acetyl-L-carnitine.

The acetylated form of L-carnitine (acetyl-L-carnitine) facilitates the release and synthesis of acetylcholine by donating its acetyl group to the production of acetylcholine, an important neurotransmitter. Acetyl-L-carnitine also enhances the release of dopamine from neurons and helps it bind to dopamine receptors.

Acetyl-L-carnitine is more effective than L-carnitine in carrying fatty acids across the membrane into the cell where they are burned as energy. With the discovery of acetyl-L-carnitine arginate, the benefits of acetyl-L-carnitine can now be greatly augmented.
References

Acetyl-L-carnitine arginate is a patented form of acetyl-L-carnitine. This patented form of carnitine seems to help protect the brain cells from neurotoxins. Since 1995, Life Extension members have been supplementing with acetyl-L-carnitine and deriving the many benefits this form of carnitine has shown in published scientific studies. With the discovery of acetyl-L-carnitine arginate, the benefits of acetyl-L-carnitine can be greatly augmented. For more information, see this product in the Brain Health section.

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D, L_Phenylalanine
500 mg 100 Capsules

L-phenylalanine is an essential amino acid which can be converted to L-tyrosine by a complex biochemical process which takes place in the liver. L-tyrosine can be converted by neurons in the brain and in the adrenal medulla of the adrenal glands to dopamine, norepinephrine (noradrenaline), and epinephrine hormones which are depleted by stress, overwork, and certain drugs. By replenishing norepinephrine in the brain, mental energy levels are enhanced and a feeling of contentment often occurs. Because of the liver conversion necessary for L-phenylalanine to have these effects, L-tyrosine is often faster acting. In addition, the conversion step from L-tyrosine to norepinephrine may be enhanced if the co-factors (vitamins B6 and C) are included.

Cells in the adrenal medulla synthesize and secrete norepinephrine and epinephrine. Since both norepinephrine and epinephrine can cause smooth muscle (arterial) contraction, care with blood pressure should be taken when supplementing L-phenylalanine or L-tyrosine.

D,L-phenylalanine is a 50/50 mixture of its two stereoisomers.

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Glutathione Cycteine & C
750 mg 100 Capsules

Glutathione (gamma-L-glutamyl-L-cysteinyl-glycine) is a peptide (short protein)-like molecule synthesized in the body from the three amino acids L-glutamic acid, L-cysteine, and glycine. Glutathione is one of the body’s most important and powerful antioxidants, helping to detoxify xenobiotics. A major function of vitamin C is to keep glutathione in its reduced form so that they can continue to provide free radical quenching effects.

Even though many published studies show that garlic, selenium, alpha-lipoic acid, L-cysteine, and N-acetylcysteine can boost cellular glutathione levels, people with health problems may benefit from taking high doses of glutathione.

L-cysteine is a conditionally essential amino acid, one of only three sulfur-containing amino acids, the others being taurine (which can be produced from L-cysteine) and L-methionine from which L-cysteine can be produced in the body by a multi-step process. Cysteine plays a role in the sulfation cycle, acting as a sulfur donor in phase II detoxification and as a methyl donor in the conversion of homocysteine to methionine. Cysteine also helps synthesize glutathione, one of the body’s most important natural detoxifiers. N-acetyl-cysteine (NAC) is the acetylated form of L-cysteine, which is more efficiently absorbed and used because it may protect the cells directly.

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L-Methionine Powder
100 grams

L-methionine is an antioxidant found in meat and dairy products. In the body, methionine acts as a methyl donor in biochemical pathways and can be converted to SAMe, a natural compound that supports liver function. Supplemental L-methionine is especially recommended for people on a vegetarian diet.

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L-Tyrosine Plus
100 grams

L-phenylalanine is an essential amino acid which can be converted to L-tyrosine by a complex biochemical process which takes place in the liver. L-tyrosine can be converted by neurons in the brain to dopamine and norepinephrine (noradrenaline), hormones which are depleted by stress, overwork and certain drugs. By replenishing norepinephrine in the brain, mental energy levels are enhanced and a feeling of contentment often occurs. Because of the liver conversion necessary for L-phenylalanine to have these effects, L-tyrosine is often faster acting. In addition, the conversion step from L-tyrosine to norepinephrine may be enhanced if the cofactors (vitamins B6 and C) are included.

Cells in the adrenal medulla synthesize and secrete norepinephrine and epinephrine. Since both norepinephrine and epinephrine can cause smooth muscle (arterial) contraction, care with blood pressure should be taken when supplementing L-phenylalanine or L-tyrosine.

L-tyrosine is also a precursor of two thyroid hormones. D-phenylalanine is unique among amino acids because the D-form (normally not found in life) has biological activity that is different from its L-stereoisomer. D, L-phenylalanine is a 50/50 mixture of the two stereoisomers.

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L-Tyrosine Powder
100 grams

L-phenylalanine is an essential amino acid which can be converted to L-tyrosine by a complex biochemical process which takes place in the liver. L-tyrosine can be converted by neurons in the brain and in the adrenal medulla of the adrenal glands to dopamine, norepinephrine (noradrenaline), and epinephrine hormones which are depleted by stress, overwork, and certain drugs. By replenishing norepinephrine in the brain, mental energy levels are enhanced and a feeling of contentment often occurs. Because of the liver conversion necessary for L-phenylalanine to have these effects, L-tyrosine is often faster acting. In addition, the conversion step from L-tyrosine to norepinephrine may be enhanced if the co-factors (vitamins B6 and C) are included.

Cells in the adrenal medulla synthesize and secrete norepinephrine and epinephrine. Since both norepinephrine and epinephrine can cause smooth muscle (arterial) contraction, care with blood pressure should be taken when supplementing L-phenylalanine or L-tyrosine.

L-tyrosine is also a precursor of two thyroid hormones.

D,L-phenylalanine is a 50/50 mixture of its two stereoisomers.

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Optimized TryptoPure® Plus
90 vegetarian capsules

L-Tryptophan is an essential amino acid, which means it cannot be synthesized by the human body and therefore must be part of the diet or supplementation. The best sources for tryptophan are high-protein foods such as oats, bananas, dried dates, dairy products, fish, many nuts, and poultry.

Tryptophan is critical in helping your body produce proteins for muscle, hair, and skin. Unfortunately,  tryptophan is the least abundant amino acid in your diet. Even a person on a high-protein diet gets less than 1.5 grams of tryptophan a day. What’s more, when you ingest tryptophan it undergoes degradation processes that dramatically reduces the amount actually available for conversion to serotonin in the brain. Some experts estimate that only 1% of the dietary tryptophan you take in reaches the brain. For some this is sufficient, but for others, low levels can adversely affect sleep, weight, and mood.

Tryptophan is a precursor for serotonin. Unlike other products that influence serotonin reuptake, L-tryptophan is a direct precursor that results in almost immediate increases in serotonin, which is one of the primary neurotransmitters involved with sleep and mood.

In those people with low serotonin levels, L-tryptophan has been shown to help establish and maintain healthy levels, which may help to improve mood and reduce tension. In those people with serotonin levels already within the normal range, L-tryptophan acts as a natural sleep aid, not only helping people fall asleep, but also helping them stay asleep throughout the night and wake without grogginess. For this reason, some experts believe tryptophan can be a safe and effective sleep aid when added to your diet as a supplement. Supplementing your diet with tryptophan, specifically TryptoPure®, may mean a more restful night’s sleep, a brighter mood, and a host of other benefits.

Life Extension has selected TryptoPure® as its tryptophan of choice. TryptoPure® is the most trusted tryptophan available today. TryptoPure® is suitable for vegetarians, additive-free, solvent-free, 100% fermented, and GMP certified.

Life Extension has developed a patent-pending formula called Optimized TryptoPure® Plus that provides lysine, niacinamide, hops, ginger and rosemary extracts to protect tryptophan against excessive degradation in our aging bodies, thus sparing it for conversion into serotonin in the brain.

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